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LL37 and released DNA can form a complex, which can activate plasmacytoid dendritic cells via internal Toll-like receptors (TLR), which then instruct T-lymphocytes to become Th1 and Th17 cells and induce production of several cytokines

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In mouse embryonic fibroblasts, the elevation of CHAC1 protein expression following As III exposure is negatively regulated by the Tribbles homolog 3 (TRIB3), which limits CHAC1s pro-death potential (rd et al., 2016)

Histological analysis of adipose tissue from 5-Amino-1MQ-treated animals reveals increased presence of multilocular brown-like adipocytes, increased mitochondrial density, elevated expression of UCP1 and other thermogenic markers, and reduced adipocyte size

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